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KMID : 1007520120210030807
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Food Science and Biotechnology
2012 Volume.21 No. 3 p.807 ~ p.814
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Perilla Oil Rich in α-Linolenic Acid Suppresses Hepatic SREBPs and NF-κB Expression in Hypercholesterolemia-induced Apolipoprotein E Knockout Mice
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Lee Ji-eun
Song Yeong-Ok
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Abstract
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This study is to examine whether perilla oil rich in α-linolenic acid, n-3 fatty acid, would affect the expression of transcription factors involved in the regulation of hepatic lipid metabolism and in the inflammatory responses. Apolipoprotein E knockout (apoE KO) mice (n=18) and its wild type mice (n=10) were fed a high cholesterol diet containing perilla oil or lard for 10 weeks. In apoE KO mice, perilla oil group demonstrated significant decrease in hepatic triglyceride (7.95%) and total cholesterol concentrations (35.76%) than lard fed group. Expression for nuclear transcription factor, sterol regulatory elementbinding protein (SREBP)-1 (32.37%) and SREBP-2 (25.6%) were dropped off whereas that for the peroxisome proliferator-activated receptor α elevated (48.15%, p<0.05), compared with lard group. Inhibition in nuclear factor-κB and increase in inhibitor κ-Bα expressions subsequently decreased cyclooxygenase-2 and inducible nitric oxide synthase expressions in the perilla oil group. Beneficial effects of perlla oil observed in apoE KO mice were greater than those from the wild type mice.
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KEYWORD
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perilla oil, apoE knockout (KO) mice, liver, sterol regulatory element-binding protein (SREBP), inflammation
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